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The science of probiotics demands precision. In collaboration with leading scientists and research partners from around the world, we develop research-backed probiotics for outcomes across gastrointestinal, dermatological, oral, pediatric, and nutritional health.

For humans, by science.

Our process starts with microbial strain validation through biofermentation, stabilization, scale-up, and clinical research.

01Strains

Density plot of microbial abundance in DS-01Density plot of microbial abundance in DS-01

Probiotic Strain
Validation

Our strain bank consists of probiotic strains with extensive mechanistic and clinical data generated at academic institutions and research partners around the world—including Italy, Spain, Belgium, US, and Japan. Our strains are deposited in the American Type Culture Collection (ATCC).

Research-Derived
Dosage

We select our strains based on robust clinical and mechanistic research, and preserve the biologically active dose of each strain in our product. Further, we ensure that the full dosage of live and active bacteria is delivered at or above label claim throughout the entire shelf life and under even the most destructive shipping temperatures.

02Biofermentation

Microscopic bacterial cells undergoing biofermentation

Biofermentation

This—a metabolic process used by bacteria to generate energy for cell growth and multiplication—is how we culture our probiotic strains. Bacteria are sensitive. They must be cultured with care to ensure viability. We optimize biofermentation conditions for pH, strain purity, temperature, and 28 other factors.

03Validation

Flow cytometry visualization

Flow Cytometry

During this process, cells are selectively tagged with fluorescent "markers" and counted by a laser as they pass through a tube. In testing for AFU (Active Fluorescent Units), flow cytometry is used to calculate a more precise measurement of all viable, injured, and dead probiotic cells, including ones that are efficacious but not necessarily culturable (and therefore, would not be counted in a traditional plated colony forming units (CFU) measurement—what you're probably used to seeing on probiotics labels).

Whole-genome sequencing visualization

Whole-Genome Sequencing

Our probiotics are among the first to undergo end-to-end, whole-genome testing—the application of nanopore and shotgun sequencing of microbial DNA to genetically validate each strain and species.

Clinical research visualization

Clinical Research

We partner with leading academic research institutions and notable Primary Investigators to validate our rationally-designed probiotic formulations through double-blind, randomized, placebo-controlled clinical trials. Our human clinical work, in combination with strain-specific clinical research and our in vitro data generation, allows us to identify novel endpoints and benefits for human health, while contributing advancements to the fields of microbiome and probiotic science.

04SHIME®

Simulator of the Human Intestinal Microbial Ecosystem (SHIME®)

Bacteria are fragile; they're sensitive to heat, oxygen, light, water, and they don't do well without protection from stomach acids or bile. With this in mind, we test our products in SHIME®, the closest system developed to model human digestion and the gut.

Simulator of the Human Intestinal Microbial EcosystemThe mouth and stomach stages of the SHIME process

Fig. 3 — To evaluate the survival of our probiotics, we use a Simulator of the Human Intestinal Microbial Ecosystem (SHIME®)—the closest system developed to model digestion and the gut. It recreates the physiological conditions and biological processes (food uptake, peristalsis, digestive enzymes, bile acids, and time spent in each step) representative of the human gastrointestinal tract.

05Testing

Seed laboratory testing illustration

Our Products

Allergen + Contaminant Testing

Our products are tested for all 14 classes of allergens according to EFSA, and Seed abides by and adheres to the stringent requirements established by CA Prop 65, or “The Safe Drinking Water and Toxic Enforcement Act of 1986”.

Quality Control

With our quality assurance and quality control (QA/QC) checkpoints, we monitor purity under both US and European protocols (including cGMP + HACCP) throughout the production cycle with no skip-lot testing. Our fermentation culture media do not contain any animal tissue or biological material.

Global Quality Adherence

We go beyond what's required for regulations enforced by the US Food and Drug Administration; we also adhere to global quality standards outlined by Japan's Foods for Specified Health Uses (FOSHU) and the European Food Safety Authority (EFSA).

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Our Scientific and Clinical Advisory Boards

Our Scientific and Clinical Advisory Boards consist of scientists and clinicians across key fields, including microbiology, computational biology, host-microbe interactions, immunology, gastroenterology and women's health. They lead labs, teach at world-renowned academic institutions, maintain regular patient-facing practices, and include members who serve as investigators from the NIH's Human Microbiome Project. These scientists and clinicians have produced 2800+ publications and over 140,000 citations in peer-reviewed scientific journals and textbooks.

Gregor Reid, PhD, MBA

Gregor Reid, PhD, MBA

Scientific Advisor

Jacques Ravel, PhD

Jacques Ravel, PhD

Scientific Advisor

George Church, PhD

George Church, PhD

Scientific Advisor

Belinda Tan, MD, PhD

Belinda Tan, MD, PhD

Scientific Advisor

James Versalovic, MD, PhD

James Versalovic, MD, PhD

Clinical Advisor

Alessio Fasano, MD

Alessio Fasano, MD

Clinical Advisor

Sarkis Mazmanian, PhD

Sarkis Mazmanian, PhD

Scientific Advisor

Christopher Mason PhD

Christopher Mason PhD

Scientific Advisor

Peter Turnbaugh, PhD

Peter Turnbaugh, PhD

Scientific Advisor

Eran Segal, PhD

Eran Segal, PhD

Scientific Advisor

Jessica Alligretti, MD, MPH

Jessica Alligretti, MD, MPH

Clinical Advisor

Jane van Dis, MD

Jane van Dis, MD

Clinical Advisor

Uma Naidoo, MD

Uma Naidoo, MD

Clinical Advisor

Emeran Mayer, MD

Emeran Mayer, MD

Clinical Advisor

Susan Kellogg-Spadt, PhD, CRNP, IF, CDC

Susan Kellogg-Spadt, PhD, CRNP, IF, CDC

Clinical Advisor

Mark Hyman, MD

Mark Hyman, MD

Clinical Advisor

Diane Harper, MD, MPH, MS

Diane Harper, MD, MPH, MS

Clinical Advisor

Nick Van Hise, PharmD

Nick Van Hise, PharmD

Clinical Advisor

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As the earliest inhabitants of this planet, microbes hold immense potential for our future. Beyond their impact as consumer probiotics, their applications range from living medicines that transform how we prevent and treat disease to environmental interventions that will address some of the most pressing challenges facing our collective home.

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DS-01® Daily Synbiotic

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